Cannabis

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance.

Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health–related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.

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"Potentially thousands of children and young people are being trafficked from Vietnam and exploited by ruthless criminal gangs."

August 21, 2018  

Experts warned Monday that large numbers of child slaves may be working on cannabis farms in London.

Since 2016, authorities have found 314 illegal cannabis farms in London, according to police data. The most alarming figures, however, come via human trafficking experts, who warn that the number of children used as slave labor on these farms is likely in the thousands.

"Experts say children are being trafficked from Vietnam and other countries to work in these farms, which are often located in residential properties, and that the scale of the problem has been vastly underestimated," Reuters reports.

The Australian human rights group, Walk Free, claims that Britain is home to 136,000 slaves. Last year, more than 2,000 child trafficking victims were reportedly referred to British authorities, the highest number on record, the group says.

"The high number of cannabis farms across London and trafficking of Vietnamese children to work in them is extremely worrying," said Jakub Sobik, a spokesman for Anti-Slavery International. "Potentially thousands of children and young people are being trafficked from Vietnam and exploited by ruthless criminal gangs."

In February, the British government came under fire for refusing asylum to an orphan from Vietnam who was trafficked to work in the cannabis industry.

"It is vital that these children are seen by police as victims first and foremost and given proper support, as too often they are treated as criminals instead," Catherine Baker, a police officer at the anti-child trafficking organization ECPAT UK, told Reuters. "These vulnerable children are exploited in extremely dangerous conditions, with little or no pay and may be physically and psychologically abused by their traffickers."

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SUMMARY 

Cannabis smoke contains many of the same carcinogens and chemicals found in tobacco smoke (Moir, Rickert et al. 2008, Wei, Alwis et al. 2016). Exposure to secondhand cannabis smoke can impair endothelial function, which increases the risk of cardiovascular disease (Wang, Derakhshandeh et al. 2016). However, US data show that the perceived health risks of marijuana use are, in fact, declining among adults (Compton, Han et al. 2016). We measured the concentrations of airborne fine particles (PM2.5) and cannabinoids at an indoor cannabis event where dabbing and vaporizing were the only cannabis emissions. We found average particle concentrations of 200-600 micrograms per m3 and peak concentrations over 1,600 micrograms per m3. Particle concentrations this high are seen in extreme air pollution events like wildfires (Landis, Edgerton et al. 2018, Li, Han et al. 2018) and severe industrial pollution (Nagar, Singh et al. 2017, Li, Han et al. 2018). Exposure at these concentrations can cause cardiovascular and respiratory disease (Zheng, Ding et al. 2015, Li, Fan et al. 2016). We show that dabbing and vaporizing cannabis can create levels of indoor air pollution that are hazardous to human health, in the absence of actual combustion. 

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Researchers report 63 percent of breast milk samples from mothers using marijuana contained traces of the drug

UNIVERSITY OF CALIFORNIA - SAN DIEGO

With the legalization of marijuana in several states, increased use for both medicinal and recreational purposes has been documented in pregnant and breastfeeding women. Although national organizations like the American Academy of Pediatrics recommend that breastfeeding mothers do not use marijuana, there has been a lack of specific data to support health or neurodevelopmental concerns in infants as a result of exposure to tetrahydrocannabinol (THC) or other components of marijuana via breast milk.

Cannabinoids -- marijuana's active compounds, such as THC -- like to bind to fat molecules, which are abundant in breast milk. This stickiness has suggested that, in women who use marijuana, these compounds can end up in breast milk, raising concerns about their potential effects on nursing babies.

"We found that the amount of THC that the infant could potentially ingest from breast milk was relatively low, but we still don't know enough about the drug to say whether or not there is a concern for the infant at any dose, or if there is a safe dosing level," said Chambers, co-director of the Center for Better Beginnings at UC San Diego. "The ingredients in marijuana products that are available today are thought to be much more potent than products available 20 or 30 years ago."

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More and more Americans are reporting near-constant cannabis use, as legalization forges ahead.

Evan, who asked that his full name not be used for fear of the professional repercussions, has a self-described cannabis-use disorder. If not necessarily because of legalization, but alongside legalization, such problems are becoming more common: The share of adults with one has doubled since the early aughts, as the share of cannabis users who consume it daily or near-daily has jumped nearly 50 percent-all "in the context of increasingly permissive cannabis legislation, attitudes, and lower risk perception," as the National Institutes of Health put it.

Public-health experts worry about the increasingly potent options available, and the striking number of constant users. "Cannabis is potentially a real public-health problem," said Mark A. R. Kleiman, a professor of public policy at New York University. "It wasn't obvious to me 25 years ago, when 9 percent of self-reported cannabis users over the last month reported daily or near-daily use. I always was prepared to say, 'No, it's not a very abusable drug. Nine percent of anybody will do something stupid.' But that number is now [something like] 40 percent." They argue that state and local governments are setting up legal regimes without sufficient public-health protection, with some even warning that the country is replacing one form of reefer madness with another, careening from treating cannabis as if it were as dangerous as heroin to treating it as if it were as benign as kombucha.

For Keith Humphreys, a professor of psychiatry and behavioral sciences at Stanford University, the most compelling evidence of the deleterious effects comes from users themselves. "In large national surveys, about one in 10 people who smoke it say they have a lot of problems. They say things like, 'I have trouble quitting. I think a lot about quitting and I can't do it. I smoked more than I intended to. I neglect responsibilities.' There are plenty of people who have problems with it, in terms of things like concentration, short-term memory, and motivation," he said. "People will say, 'Oh, that's just you fuddy-duddy doctors.' Actually, no. It's millions of people who use the drug who say that it causes problems."

Users or former users I spoke with described lost jobs, lost marriages, lost houses, lost money, lost time. Foreclosures and divorces. Weight gain and mental-health problems. And one other thing: the problem of convincing other people that what they were experiencing was real. A few mentioned jokes about Doritos, and comments implying that the real issue was that they were lazy stoners. Others mentioned the common belief that you can be "psychologically" addicted to pot, but not "physically" or "really" addicted. The condition remains misunderstood, discounted, and strangely invisible, even as legalization and white-marketization pitches ahead.

Academics and public-health officials, though, have raised the concern that cannabis's real risks have been overlooked or underplayed-perhaps as part of a counter-reaction to federal prohibition, and perhaps because millions and millions cannabis users have no problems controlling their use. "Part of how legalization was sold was with this assumption that there was no harm, in reaction to the message that everyone has smoked marijuana was going to ruin their whole life," Humphreys told me. It was a point Kleiman agreed with. "I do think that not legalization, but the legalization movement, does have a lot on its conscience now," he said. "The mantra about how this is a harmless, natural, and non-addictive substance-it's now known by everybody. And it's a lie."

Thousands of businesses, as well as local governments earning tax money off of sales, are now literally invested in that lie. "The liquor companies are salivating," Matt Karnes of GreenWave Advisors told me. "They can't wait to come in full force." He added that Big Pharma was targeting the medical market, with Wall Street, Silicon Valley, food businesses, and tobacco companies aiming at the recreational market.

Other people who found their use problematic or had managed to quit, none of whom wanted to use their names, described similar struggles and consequences. "I was running two companies at the time, and fitting smoking in between running those companies. Then, we sold those companies and I had a whole lot of time on my hands," one other former cannabis user told me. "I just started sitting around smoking all the time. And things just came to a halt. I was in terrible shape. I was depressed."

Lax regulatory standards and aggressive commercialization in some states have compounded some existing public-health risks, raised new ones, and failed to tamp down on others, experts argue. In terms of compounding risks, many cite the availability of hyper-potent marijuana products. "We're seeing these increases in the strength of cannabis, as we are also seeing an emergence of new types of products," such as edibles, tinctures, vape pens, sublingual sprays, and concentrates, Ziva Cooper, an associate professor of clinical neurobiology in the Department of Psychiatry at Columbia University Medical Center, told me. "A lot of these concentrates can have up to 90 percent THC," she said, whereas the kind of flower you could get 30 years ago was far, far weaker. Scientists are not sure how such high-octane products affect people's bodies, she said, but worry that they might have more potential for raising tolerance, introducing brain damage, and inculcating dependence.

As for new risks: In many stores, budtenders are providing medical advice with no licensing or training whatsoever. "I'm most scared of the advice to smoke marijuana during pregnancy for cramps," said Humphreys, arguing that sellers were providing recommendations with no scientific backing, good or bad, at all.

In terms of long-standing risks, the lack of federal involvement in legalization has meant that marijuana products are not being safety-tested like pharmaceuticals; measured and dosed like food products; subjected to agricultural-safety and pesticide standards like crops; and held to labeling standards like alcohol. (Different states have different rules and testing regimes, complicating things further.)

Health experts also cited an uncomfortable truth about allowing a vice product to be widely available, loosely regulated, and fully commercialized: Heavy users will make up a huge share of sales, with businesses wanting them to buy more and spend more and use more, despite any health consequences.

"The reckless way that we are legalizing marijuana so far is mind-boggling from a public-health perspective," Kevin Sabet, an Obama administration official and a founder of the nonprofit Smart Approaches to Marijuana, told me. "The issue now is that we have lobbyists, special interests, and people whose motivation is to make money that are writing all of these laws and taking control of the conversation."

Then, there are THC taxes, designed to hit heavy users the hardest. Some drug-policy experts argue that such levies would just push people from marijuana to alcohol, with dangerous health consequences. "It would be like saying, 'Let's let the beef and pork industries market and do whatever they wish, but let's have much tougher restrictions on tofu and seitan,'" said Mason Tvert of the Marijuana Policy Project. "In light of the current system, where alcohol is so prevalent and is a more harmful substance, it is bad policy to steer people toward that." Yet reducing the commercial appeal of all vice products-cigarettes, alcohol, marijuana-is an option, if not necessarily a popular one.

Perhaps most important might be reintroducing some reasonable skepticism about cannabis, especially until scientists have a better sense of the health effects of high-potency products, used frequently. Until then, listening to and believing the hundreds of thousands of users who argue marijuana is not always benign might be a good start.

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